Frederick S Buckner Selected Research

p21(ras) farnesyl-protein transferase (protein farnesyltransferase)

2/2006	Thematic review series: lipid posttranslational modifications. Fighting parasitic disease by blocking protein farnesylation.
8/2005	The protein farnesyltransferase inhibitor Tipifarnib as a new lead for the development of drugs against Chagas disease.
6/2005	Protein farnesyltransferase inhibitors exhibit potent antimalarial activity.
8/2002	Isothiazole dioxides: synthesis and inhibition of Trypanosoma brucei protein farnesyltransferase.

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Frederick S Buckner Research Topics

Disease

15	Chagas Disease (American Trypanosomiasis) 01/2016 - 12/2003
13	African Trypanosomiasis (Nagana) 02/2020 - 08/2002
12	Malaria 05/2013 - 02/2003
5	Neglected Diseases 02/2020 - 12/2010
5	Infections 01/2020 - 02/2003
3	Leishmaniasis 01/2016 - 06/2009
3	Neoplasms (Cancer) 05/2010 - 03/2009
2	Trypanosomiasis 01/2021 - 07/2017
2	Cryptosporidiosis 01/2021 - 01/2019
2	Visceral Leishmaniasis (Kala Azar) 07/2017 - 06/2009
2	Brucellosis (Malta Fever) 01/2016 - 01/2016
2	Drug-Related Side Effects and Adverse Reactions 08/2015 - 01/2008
2	Parasitemia 07/2014 - 09/2012
2	Parasitic Diseases (Parasitic Disease) 02/2006 - 02/2003
1	Cutaneous Leishmaniasis 10/2021
1	Cysts 01/2020
1	Giardiasis 01/2020
1	Amebiasis (Amoebiasis) 01/2019
1	Tuberculosis (Tuberculoses) 01/2018
1	Gram-Positive Bacterial Infections 11/2017
1	Communicable Diseases (Infectious Diseases) 06/2011
1	Rare Diseases (Rare Disease) 01/2011
1	Chagas Cardiomyopathy 09/2006
1	Mycoses (Diseases, Fungus) 02/2003

Drug/Important Bio-Agent (IBA)

20	Pharmaceutical PreparationsIBA 01/2021 - 02/2003
8	Methionine-tRNA LigaseIBA 01/2020 - 05/2011
7	Proteins (Proteins, Gene)FDA Link 01/2018 - 02/2003
6	EnzymesIBA 01/2018 - 02/2003
5	tipifarnib (R115777)IBA 01/2019 - 08/2005
5	Antiparasitic Agents (Antiparasitics)IBA 01/2017 - 07/2013
5	posaconazole FDA Link 07/2014 - 01/2008
4	p21(ras) farnesyl-protein transferase (protein farnesyltransferase)IBA 02/2006 - 08/2002
3	SterolsIBA 12/2013 - 09/2012
3	Farnesyltranstransferase (Farnesyltransferase)IBA 09/2008 - 08/2005
2	imidazopyridineIBA 01/2021 - 01/2019
2	Urea (Carbamide)FDA LinkGeneric 01/2017 - 07/2012
2	Sterol 14-DemethylaseIBA 12/2012 - 01/2008
2	benzonidazole (benznidazole)IBA 09/2012 - 01/2008
2	LanosterolIBA 05/2010 - 06/2009
2	TransferasesIBA 08/2005 - 02/2003
1	miltefosine (Impavido)IBA 10/2021
1	pyrimidineIBA 01/2021
1	Amino Acyl-tRNA Synthetases (Aminoacyl-tRNA Synthetase)IBA 01/2021
1	Anti-Infective Agents (Microbicides)IBA 01/2021
1	LuciferasesIBA 01/2020
1	nanolucIBA 01/2020
1	NitroimidazolesIBA 01/2019
1	nitazoxanide (NTZ)FDA Link 01/2019
1	lonafarnib (SCH 66336)IBA 01/2019
1	Metronidazole (Metric)FDA LinkGeneric 01/2019
1	Adenine FDA LinkGeneric 01/2018
1	Anti-Bacterial Agents (Antibiotics)IBA 11/2017
1	compound 20IBA 07/2017
1	BenzamidesIBA 01/2017
1	AminesIBA 01/2017
1	GNF6702IBA 01/2016
1	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2016
1	Calcium Channel Blockers (Blockers, Calcium Channel)IBA 07/2014
1	Amlodipine (Norvasc)FDA LinkGeneric 07/2014
1	Clemastine (Clemastine Fumarate)FDA LinkGeneric 07/2014
1	Transfer RNA (tRNA)IBA 05/2013
1	Ligases (Synthetase)IBA 05/2013
1	ER 30346 (ravuconazole)IBA 12/2012
1	14-alpha Demethylase InhibitorsIBA 12/2012
1	ProdrugsIBA 12/2012
1	methioninyl adenylateIBA 10/2012
1	aminoquinoloneIBA 10/2012
1	Methionine (L-Methionine)FDA Link 10/2012
1	AzolesIBA 09/2012
1	Ergosterol (Lumisterol)IBA 05/2010
1	isoquinolineIBA 12/2009
1	IsoquinolinesIBA 12/2009
1	LigandsIBA 07/2009
1	ImidazolesIBA 06/2009
1	beta-Lactamases (beta-Lactamase)IBA 06/2009
1	Glycogen Synthase Kinase 3IBA 10/2008
1	Adenosine DeaminaseIBA 09/2008
1	ethylenediamine (ethylenediamine dihydroiodide)FDA Link 09/2008
1	NifurtimoxIBA 01/2008
1	Ketoconazole (Nizoral)FDA LinkGeneric 01/2008
1	TriazolesIBA 01/2008
1	Itraconazole (Sporanox)FDA LinkGeneric 01/2008
1	Amino Acids FDA Link 01/2008
1	ICI 195739IBA 01/2008
1	Oxidoreductases (Dehydrogenase)IBA 03/2006

Therapy/Procedure

11	Therapeutics 01/2020 - 02/2003
1	Drug Therapy (Chemotherapy) 01/2011
1	Heart Transplantation (Grafting, Heart) 09/2006
1	Blood Transfusion (Blood Transfusions) 12/2003